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Image Search Results
Journal: Biomedicines
Article Title: Highly Sensitive and Quantitative Diagnosis of SARS-CoV-2 Using a Gold/Platinum Particle-Based Lateral Flow Assay and a Desktop Scanning Electron Microscope
doi: 10.3390/biomedicines10020447
Figure Lengend Snippet: Comparison of lateral flow assay (LFA) detection methods for SARS-CoV-2 using clinical samples: ( a ) The accuracy of visual diagnosis was assessed by testing SARS-CoV-2-negative and -positive patients using qRT-PCR and the antigen solutions from the same patients, and then calculated the area under the curve (AUC) for the receiver operating characteristic (ROC) curve. ( b ) Detection via scanning electron microscopy (SEM) using the test line (TL)/background area (BA) ratio. A TL/BA ratio of 1.975 was chosen as the threshold cut-off value based on the ROC curve study to differentiate SARS-CoV-2 infection. ( c ) TL/BA ratio (log10) and cycle threshold (Ct) scatter plot. Triple-positive results (“visual detection-positive”, “SEM detection-positive”, and “qRT-PCR detection-positive”) are represented with blue dots, double-positive results (“SEM detection-positive” and “qRT-PCR detection-positive”) are represented with red dots, and single-positive results (“qRT-PCR detection-positive”) are represented with green dots. The approximate slope is indicated by the blue dotted line.
Article Snippet: Although it is difficult to accurately compare the cost because of the differences in equipment and kits, the cost of the
Techniques: Comparison, Lateral Flow Assay, Biomarker Discovery, Quantitative RT-PCR, Electron Microscopy, Infection